Chemistry Blog of RC Mishra

Recent review article in DDT (Drug Discovery Today)

Drug Discovery in the era of Facebook-new tools for scientific networking).

Your Paper Is A Sack Of Raving Nonsense. Thank You.. In the Pipeline:.

The Article:

Substrate Modification Approach to Achieve Efficient Resolution:  Didesmethylcitalopram:  A Key Intermediate for Escitalopram

pp 289–292

Derek, The famous chemical blogger wrote in his blog In the Pipeline, this very useful article about the hydrogenation reactions using Pd/C catalysts. Article as well as comments worth to have a look for any synthetic chemist.

Just follow the link below…and don’t forget to post your opinion in case you feel something after reading everybody’s comment.

Reduce Your Number of Reductions, Why Don’t You?. In the Pipeline:.

Sexy gene conversions: locating gene conversions on the X-chromosome.

This is an interesting article published in Genomics section of the journal Nucleic Acid Research by researchers at Virginia Tech.

Learning From UCLA | Science & Technology | Chemical & Engineering News.

Below is embedded a Java Applet which can help you draw Chemical Structures of your choice.

The manuscript titled Adenine based acyclic-nucleotides as novel P2X3 receptor ligands has been accepted for publication in Journal of Medicinal Chemistry published by American Chemical Society.

Authors: Volpini Rosaria; Mishra, RC; Kachare DD; Dalben Diego; Catia Lambertucci; Ippolito Antonini; Vittori sauro; Marucci Gabriella and Nistri Andrea

The article titled above has been published in the Journal CHEMMEDCHEM.

ChemMedChem

Special Issue: XIX NMMC Verona 2008

Published Online: 2 Apr 2009

Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA

Full Paper

^*Correspondence to Rosaria Volpini, ¹Dipartimento di Scienze Chimiche, Università di Camerino via S. Agostino 1, 62032 Camerino (MC) (Italy), Fax: (+39) 0737-402295

Funded by:
Italian Ministry for University and Research; Grant Number: PRIN2006, FIRB RBN503YA3L project

A new series of 8-substituted 9-ethyladenine derivatives has been synthesized and tested at rat and human adenosine receptors. Binding data demonstrates that some compounds could represent new tools suitable for in vivo studies in rat models of Parkinson’s disease and for the design of new molecules with improved affinity and selectivity at human AA2AR.

Clinical evidence has demonstrated that AA2AR antagonists could be an alternative approach to the treatment of Parkinson’s disease. Recently, three 9-ethyladenine derivatives bearing a bromine atom, an ethoxy group, and a furyl ring, respectively, in the 8-position have been reported to ameliorate motor deficits in rat Parkinson’s disease models, suggesting a potential therapeutic role for these compounds. Starting from these observations, a new series of 9-ethyladenine derivatives, bearing different substituents such as halogens, alkoxy groups, aromatic and heteroaromatic rings in the 8-position, were synthesized. Radioligand binding assays demonstrated that some of the new compounds bind rat AA2AR with higher affinity than the previously reported congeners and that there is a good correlation between binding to rat and human receptors. Hence, the new molecules could represent new tools suitable for the in vivo studies in rat models of Parkinson’s disease. Finally, a molecular docking analysis of the compounds was performed using a homology model of rat AA2AR, built using the human crystal structure as the template, and results are in agreement with the binding data.

10.1002/cmdc.200800434  About DOI

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